Pediatric Anaplastic Large Cell Lymphoma with Concomitant Involvement of Spine and Central Nervous System: A Case Report and Review of Literature

Anaplastic large cell lymphoma (ALCL) is a histological subtype of non-Hodgkin lymphoma, largely characterized by anaplastic kinase (ALK) positivity, resulting from the chromosomal translocation t(2;5). We report pediatric case ALK-positive ALCL with primary concomitant involvement bone and central nervous system (CNS); thereafter, literature review about CNS was conducted. According to analyzed data, our unique because it contemporary spine CNS. During after chemotherapy, patient monitored detecting minimal residual disease (MRD) through analysis fusion transcript nucleophosmin-ALK. MRD assessment, not only in marrow but also peripheral blood, seems be very powerful tool for predicting prognosis patients, as already described literature. Moreover, shown case, could used during follow-up early recognition relapse.